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The Global Research Library

A reading room for everyone. Filter peer-reviewed autoimmune research, read the abstract next to a plain-language summary, save it to your reading list, and copy a formatted citation in one click.
Evidence keyEstablished evidenceEmerging evidenceOngoing research

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Index powered by open bibliographic records PubMed

Established evidenceLongitudinal cohortLandmark discoveries

Longitudinal analysis reveals high prevalence of Epstein-Barr virus associated with multiple sclerosis

Bjornevik K, Cortese M, Healy BC, et al. · Science · 2022 · Harvard T.H. Chan School of Public Health, United States

DOI: 10.1126/science.abj8222

In plain language

Researchers followed millions of people over years. People who caught Epstein-Barr virus (the mono virus) were far more likely to develop MS later. It does not mean everyone with EBV gets MS — almost everyone gets EBV — but it appears to be a necessary step.

Open source
Established evidencePhase 3 randomized controlled trialLandmark clinical trials

Trial of anifrolumab in active systemic lupus erythematosus

Morand EF, Furie R, Tanaka Y, et al. · New England Journal of Medicine · 2020 · Monash University, International

DOI: 10.1056/NEJMoa1912196

In plain language

A medicine that blocks an inflammation signal called interferon helped more people with lupus improve than a dummy treatment did. It later became an approved lupus therapy.

Open source
Established evidenceRandomized controlled trialLandmark clinical trials

An anti-CD3 antibody, teplizumab, in relatives at risk for type 1 diabetes

Herold KC, Bundy BN, Long SA, et al. · New England Journal of Medicine · 2019 · Yale School of Medicine / TrialNet, United States

DOI: 10.1056/NEJMoa1902226

In plain language

A two-week infusion delayed the start of type 1 diabetes by roughly two years in people who were already on track to develop it. It was the first therapy shown to postpone the disease.

Open source
Established evidenceClinical practice guidelineGuidelines

EULAR recommendations for the management of systemic lupus erythematosus: 2023 update

Fanouriakis A, Kostopoulou M, Andersen J, et al. · Annals of the Rheumatic Diseases · 2024 · EULAR, Europe

DOI: 10.1136/ard-2023-224762

In plain language

European specialists reviewed the evidence and agreed on how lupus should be treated today, including using as little steroid as possible and aiming for remission.

Open source
Emerging evidenceExperimental / mouse and humanSex & hormones

Xist ribonucleoproteins promote female sex-biased autoimmunity

Dou DR, Zhao Y, Belk JA, et al. · Cell · 2024 · Stanford University School of Medicine, United States

DOI: 10.1016/j.cell.2023.12.037

In plain language

A molecule that only exists in cells with two X chromosomes may help explain why women get autoimmune diseases far more often. This is early-stage science, not yet a treatment.

Open source
Ongoing researchSystematic reviewEmerging therapies

The gut microbiome in rheumatoid arthritis: mechanisms and therapeutic potential

Zhao T, Wei Y, Zhu Y, et al. · Frontiers in Immunology · 2022 · Peking University, China

DOI: 10.3389/fimmu.2022.1007165

In plain language

Gut bacteria may influence how rheumatoid arthritis starts. The link is real but the details, and whether changing bacteria treats disease, are still being studied.

Open source
Emerging evidenceCase seriesEmerging therapies

CD19-targeted CAR T cells in refractory systemic autoimmune disease

Müller F, Taubmann J, Bucci L, et al. · New England Journal of Medicine · 2024 · Friedrich-Alexander-Universität Erlangen-Nürnberg, Germany

DOI: 10.1056/NEJMoa2308917

In plain language

Doctors reprogrammed patients' own immune cells to wipe out the cells making harmful antibodies. A small group went into remission without further drugs. Very promising, but early and only in a few people so far.

Open source
Emerging evidenceRandomized controlled trialNutrition

Vitamin D and marine omega-3 fatty acid supplementation and incident autoimmune disease (VITAL)

Hahn J, Cook NR, Alexander EK, et al. · BMJ · 2022 · Brigham and Women's Hospital / Harvard Medical School, United States

DOI: 10.1136/bmj-2021-066452

In plain language

In a large trial of older adults, taking vitamin D for five years slightly lowered the chance of developing an autoimmune disease. The effect was modest, and results may not transfer to younger people.

Open source
Established evidenceEpidemiological modelling studyEpidemiology

Global, regional and national burden of rheumatoid arthritis 1990-2020

GBD Rheumatoid Arthritis Collaborators · The Lancet Rheumatology · 2023 · Institute for Health Metrics and Evaluation, Global

DOI: 10.1016/S2665-9913(23)00211-4

In plain language

A worldwide study counted how many people live with rheumatoid arthritis in every country, and showed the burden is growing as populations age.

Open source
Established evidencePopulation-based cohort (22 million people)Landmark discoveries

Incidence, prevalence, and co-occurrence of autoimmune disorders over time and by age, sex, and socioeconomic status

Conrad N, Misra S, Verbakel JY, et al. · The Lancet · 2023 · University of Oxford / KU Leuven, United Kingdom

DOI: 10.1016/S0140-6736(23)00457-9

In plain language

Looking at 22 million health records, about 1 in 10 people had an autoimmune condition — and women were affected much more often than men.

Open source
Emerging evidenceSystematic review & meta-analysisNutrition

Mediterranean diet and inflammatory markers: a systematic review and meta-analysis

Koelman L, Egea Rodrigues C, Aleksandrova K · Advances in Nutrition · 2022 · German Institute of Human Nutrition, Germany

DOI: 10.1093/advances/nmab086

In plain language

Eating a Mediterranean-style diet — vegetables, legumes, olive oil, fish — is linked with lower inflammation markers in the blood. It supports overall health but is not a treatment for autoimmune disease.

Open source
Established evidenceEvidence-based recommendationLifestyle

Effects of exercise therapy in rheumatoid arthritis: an updated review

Rausch Osthoff AK, Niedermann K, Braun J, et al. · Annals of the Rheumatic Diseases · 2018 · EULAR Task Force, Europe

DOI: 10.1136/annrheumdis-2018-213585

In plain language

European rheumatology experts concluded that regular, appropriately adapted exercise should be a normal part of arthritis care — it is safe and helps.

Open source